Synthesis, Characterisation and Bioactivity Evaluation of Group 10 Metal N-Heterocyclic Carbene (NHC) Complexes

Metal N-heterocyclic carbene (NHC) complexes have emerged as a new platform to look for novel therapeutic alternatives to treat cancers and infectious diseases over the past two decades. This thesis reported the synthesis and characterization of a series of racemic pyridine-functionalised nickel, palladium and platinum NHC complexes, and these metal complexes were evaluated for their in vitro antimicrobial activities and cytotoxicities against selected cancer cells. In this study, evidences for the influence of metals, wingtip substituents on the NHC ring and optical isomerism on the biological activities of these metal NHC complexes have been found.