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Sympathetic nervous system activity, chronic low grade inflammation and insulin resistance in pathophysiology of Polycystic Ovary Syndrome

thesis
posted on 19.11.2018, 06:14 by SOULMAZ SHORAKAE
This thesis identifies and addresses important knowledge gaps in our understanding of PCOS pathophysiology, also generates new insights into the mechanisms underlying increased cardiometabolic risks in PCOS. I examined the role of sympathetic dysfunction and chronic low grade inflammation in the pathophysiology of PCOS. My findings suggest a close association of sympathetic activity with chronic low-grade inflammation and with development of insulin resistance, hyperandrogenism and potentially the subsequent metabolic abnormalities in PCOS. I report moxonidine is not effective in modulating sympathetic activity in PCOS however may exert anti-inflammatory effects. This will inform future clinical trials in amelioration of PCOS features.

History

Principal supervisor

Helena Jane

Additional supervisor 1

Barbora de Courten

Additional supervisor 2

Gavin Lambert

Year of Award

2018

Department, School or Centre

Public Health and Preventive Medicine

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences