Monash University

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Reason: Under embargo until November 2019. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Sympathetic nervous system activity, chronic low grade inflammation and insulin resistance in pathophysiology of Polycystic Ovary Syndrome

posted on 2018-11-19, 06:14 authored by SOULMAZ SHORAKAE
This thesis identifies and addresses important knowledge gaps in our understanding of PCOS pathophysiology, also generates new insights into the mechanisms underlying increased cardiometabolic risks in PCOS. I examined the role of sympathetic dysfunction and chronic low grade inflammation in the pathophysiology of PCOS. My findings suggest a close association of sympathetic activity with chronic low-grade inflammation and with development of insulin resistance, hyperandrogenism and potentially the subsequent metabolic abnormalities in PCOS. I report moxonidine is not effective in modulating sympathetic activity in PCOS however may exert anti-inflammatory effects. This will inform future clinical trials in amelioration of PCOS features.


Principal supervisor

Helena Jane

Additional supervisor 1

Barbora de Courten

Additional supervisor 2

Gavin Lambert

Year of Award


Department, School or Centre

Public Health and Preventive Medicine


Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences