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Reason: Under embargo until 6 June 2025. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Study of Chemoresistance Mechanisms and Potential Alternate Therapy in Colorectal Cancers

thesis
posted on 2024-06-06, 02:35 authored by ZHIJACK FONG
Chemoresistance is a significant treatment challenge in colorectal cancers (CRC). This thesis describes apoptosis inhibition as pivotal mechanism conferring CRC chemoresistance, confirmed through bioinformatics analysis and laboratory experiments using cisplatin-resistant CRC cell models that were established in this study. This thesis also explores ferroptosis in overcoming chemoresistance. Combining cisplatin with the ferroptosis inducer RSL3 demonstrates synergistic anticancer effect, particularly in cisplatin-resistant CRC cells, offering a potential avenue to overcome chemoresistance. These findings underscore the importance of understanding and targeting apoptosis evasion and ferroptosis induction in CRC therapy, warranting further investigation into their clinical applications.

History

Campus location

Malaysia

Principal supervisor

Lee Wai Leng

Additional supervisor 1

Tan Hock Siew

Year of Award

2024

Department, School or Centre

School of Sciences (Monash University Malaysia)

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Science

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