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Studies on the aetiology and evaluation of thyroid disease
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posted on 08.02.2017, 04:10by Topliss, Duncan
This thesis is concerned with two broad categories
of thyroid related research: the aetiology of autoimmune
thyroid disease, and the nuclear basis of thyroid
hormone action. Whereas the first is directly related
to disease, the research in the second area is intended
as a contribution to eventual better understanding of
the pathophysiology of thyroid dysfunction, and nonthyroidal
illness as it affects thyroid hormone action.
The research concerning the aetiology of autoimmune
thyroid disease utilized the technique of T lymphocyte
migration inhibition testing and was designed to test
the hypothesis of suppressor T cell deficiency as a
pathogenetic mechanism in autoimmune thyroid disease.
Migration of T lymphocytes in the presence or absence of
specific antigen was displayed by projection microscopy
and measured by planimetry. Inhibition in response to
thyroid antigen was found in Graves' disease (GD) and
Hashimoto's thyroiditis (HT) but not in normal
individuals. The addition of a low ratio of normal
T lymphocytes to the GD or HT T lymphocytes abolished
the migration inhibition whereas admixture with other GD
or HT lymphocytes did not, suggesting the possibility
that a specific T lymphocyte deficit, i.e. in suppressor
cell function, was being corrected.