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Studies on the Effects of Hypoxia and Creatine Availability on Mitochondrial Dynamics During Pregnancy

thesis
posted on 26.02.2021, 07:37 by ANNA MARIA MUCCINI
Throughout gestation, the constant supply of oxygen and nutrients support fetal growth and development. Placental insufficiencies or intrapartum complications can compromise this oxygen supply and have catastrophic consequences on what was otherwise a healthy pregnancy. At a cellular level, multi-organ injury develops due to mitochondrial dysfunction. Creatine is an essential dietary metabolite and a cellular energy buffer with the potential to sustain mitochondrial health and prevent the adverse outcomes of these pregnancy complications. The primary focus of this thesis was to assess whether creatine supplementation mediates protection by supporting mitochondrial dynamics in the placenta and the fetus.

History

Principal supervisor

Stacey Joan Ellery

Additional supervisor 1

David Walker

Additional supervisor 2

Matthew McKenzie

Year of Award

2021

Department, School or Centre

Obstetrics and Gynaecology

Additional Institution or Organisation

Ritchie Centre

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

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