Monash University

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Reason: Under embargo until February 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Studies on the Effects of Hypoxia and Creatine Availability on Mitochondrial Dynamics During Pregnancy

posted on 2021-02-26, 07:37 authored by ANNA MARIA MUCCINI
Throughout gestation, the constant supply of oxygen and nutrients support fetal growth and development. Placental insufficiencies or intrapartum complications can compromise this oxygen supply and have catastrophic consequences on what was otherwise a healthy pregnancy. At a cellular level, multi-organ injury develops due to mitochondrial dysfunction. Creatine is an essential dietary metabolite and a cellular energy buffer with the potential to sustain mitochondrial health and prevent the adverse outcomes of these pregnancy complications. The primary focus of this thesis was to assess whether creatine supplementation mediates protection by supporting mitochondrial dynamics in the placenta and the fetus.


Principal supervisor

Stacey Joan Ellery

Additional supervisor 1

David Walker

Additional supervisor 2

Matthew McKenzie

Year of Award


Department, School or Centre

Clinical Sciences at Monash Health

Additional Institution or Organisation

Obstetrics and Gynaecology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses