J Hutchison REVISED THESIS FINAL.pdf (22.97 MB)
Studies on Obesity-Associated Advanced Glycation Endproducts and Female Fertility
thesisposted on 2021-06-22, 03:21 authored by JENNIFER CLAIRE HUTCHISON
My thesis examined how obesity affects fertility, both how it impacts the mother and the baby. Enriched in the uterine fluid of obese women are Advanced Glycation Endproducts, a proinflammatory modification of sugars and proteins, which are formed when foods are browned during cooking- the golden colour on a morning slice of toast. When in the uterine fluid Advanced Glycation Endproducts compromise the development of the early embryo and how it interacts with the mother. Elevated AGEs are detrimental to fertility, and in the clinic, preconception reduction of uterine AGEs may improve the fertility of obese women.