Studies of the Structural Basis for DNA Transcription of Housekeeping Genes

The development of a multicellular organism requires synthesis of many thousands of different messenger RNAs (mRNAs), at exactly the right time, in the right set of cells, and in the right amount. Thus, the need for stringent regulation of gene expression arises. Understanding the mechanism and regulation of RNA polymerases is vital for the understanding of the regulation of transcription initiation—the most important level of control of gene expression.