Monash University

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Reason: Under embargo until 8 January 2027. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Structure Engineering of Chromatograph Membranes for Improved Protein Separation

posted on 2024-01-08, 08:44 authored by XUEFENG LI
With growing health consciousness, the demand for therapeutic monoclonal antibodies has surged. Meeting this high demand poses significant challenges in manufacturing. Traditional methods are inadequate, and a new membrane chromatography technique is pivotal in addressing this issue. This method leverages synthetic macroporous and microporous membranes as chromatographic media, mitigating several problems associated with packed bed chromatography. Achieving uniform distribution of ligands or copolymers on the membrane backbone is crucial. The ultimate goal is to combine the benefits of these membranes, along with effective ligand or copolymer distribution, to achieve superior protein separation performance and high production yields.


Campus location


Principal supervisor

Huanting Wang

Additional supervisor 1

Xiwang Zhang

Additional supervisor 2

Gao Li

Year of Award


Department, School or Centre

Chemical & Biological Engineering


Doctor of Philosophy

Degree Type



Faculty of Engineering