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Structural characterization of regulatory proteins useful in developing biosensors for water purification systems
In order to distinguish essays and pre-prints from academic theses, we have a separate category. These are often much longer text based documents than a paper.
posted on 18.12.2017by Shamayeeta Ray
thesis focuses on structural characterization of a bacterial protein, MopR,
that is involved in direct sensing of toxic aromatic pollutants from the
environment and hence, can provide a suitable scaffold for phenolic biosensor
design. However, due to lack of any structural information till date, accurate
biosensor design was impeded. Here, in this work, the first x-ray structure of
the phenol sensing domain of MopR has been solved in complex with phenol
derivatives which reveals the exact pollutant binding pocket architecture,
which in turn, helped in designing a series of sensitive and selective
biosensors for different phenolic pollutants accurately, by logic-based
tweaking of the pocket.