Monash University

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Structural characterisation of molecular interactions in the RIG-I antiviral signalling pathway

posted on 2018-07-20, 02:53 authored by NEELAM SHAH
The innate immune system serves to detect foreign infectious pathogens as a first line of the body's defence. After microbes, such as viruses, overcome the physical and chemical barriers, various cells in our body are capable of detecting these infectious viruses. These cells initiate a set of reactions generally known as antiviral innate immune responses. Several proteins within the cell, such as RIG-I like receptors, detect the virus-derived molecules and initiate a signalling cascade. This results in the production of antiviral cytokines such as type I interferons (IFN) and subsequent enzymes for impairing viral replication and resolving viral infection.


Principal supervisor

Jacqueline Anne Wilce

Additional supervisor 1

Matthew C.J Wilce

Additional supervisor 2

Simone A. Beckham

Year of Award


Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Biochemistry and Molecular Biology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses