Monash University
Thesis_Bayly-Jones_2021_ammended.pdf (123.95 MB)

Structural and functional characterisation of MACPF proteins in immunity

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posted on 2021-03-23, 13:39 authored by Charles Bayly-Jones
The human immune system consists of hundreds of thousands of nanoscopic molecular machines, referred to as proteins. This thesis explores a group called pore forming proteins, which self-assemble into ring structures in order to insert into and puncture cell barriers. These agents maintain human health by targeting and destroying rogue cells or invading pathogens. If left unchecked, however, the immune system can damage the body. This thesis visualised nanoscopic details of the architecture and organisation of these potent effectors. These findings provide an understanding of the function of these immune weapons and the underlying molecular mechanisms of certain immune diseases.


Principal supervisor

Michelle Anne Dunstone

Additional supervisor 1

James C. Whisstock

Additional supervisor 2

Siew Siew Pang

Additional supervisor 3

Paul Conroy

Year of Award


Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Biochemistry and Molecular Biology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences