Structural and Pharmacological Investigation of the P2X1 Receptor as a Drug Target

One of the most intriguing therapeutic applications for the P2X1 receptor is its potential use as a male contraceptive. The high prevalence of unintended pregnancies, limited male contraceptive options, and promising initial studies suggest significant benefits. However, the P2X1 receptor is poorly understood or effectively targeted by drugs. Using an array of structural and functional approaches we determined and characterised the first P2X1 receptor structure and used this information to discover new drugs targeting the receptor. The work in this thesis brings us closer to the ultimate goal of developing an oral male contraceptive pill.