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Structural and Functional Studies of Human Plasminogen and Cofactors

thesis
posted on 28.05.2017 by JUINN HUEI QUEK
Plasminogen is the inactive precursor of Plasmin, a protease with diverse physiological roles such as the removal of blood clots and wound healing. Plasminogen/Plasmin are important therapeutic targets especially in stroke and heart attack but to date, the mechanism behind Plasminogen activation remains largely unclear. This thesis focuses on the studies of (co-)factors affecting Plasminogen activation via biophysical and biochemical methods. It was found that sugar modification (glycosylation) significantly impacts Plasminogen activation and furthermore, striking differences were observed when Plasminogen activators isolated from human and bacterial pathogen were compared. Overall, this work has advanced our understanding of the Plasminogen/Plasmin system.

History

Principal supervisor

James Whisstock

Additional supervisor 1

Ruby Law

Year of Award

2017

Department, School or Centre

Biochemistry and Molecular Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

Doctorate

Faculty

Faculty of Medicine Nursing and Health Sciences

Exports

Exports