Balu Thesis final.pdf (17.66 MB)
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Structural Characterisation and Engineering of the Single Disulfide-Directed β-Hairpin (SDH) Fold

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thesis
posted on 12.11.2018, 04:30 authored by BALASUBRAMANYAM CHITTOOR
“This thesis examines the potential of single disulfide directed β-hairpin fold identified in a peptide contryphan-Vc1, from an Australian cone snail Conus victoriae as a peptide scaffold. It establishes different aspects of stability of contryphan-Vc1 and is shown to accept short epitopes without disrupting its structure. An attempt to enhance the SDH fold as a peptide scaffold is made by engineering an additional disulfide bridge in the contryphan-Vc1. This thesis also examines the lipid binding property of contryphan-Vc1 using dodecylphospocholine micelles and also tries to identify crucial residues for folding and maintenance of the SDH fold.”

History

Campus location

Australia

Principal supervisor

Raymond Stanley Norton

Year of Award

2018

Department, School or Centre

Medicinal Chemistry

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences