Strategies for the improvement of Ti-6Al-4V implant osseointegration
thesisposted on 12.03.2019 by TRINA MAJUMDAR
In order to distinguish essays and pre-prints from academic theses, we have a separate category. These are often much longer text based documents than a paper.
Titanium-based alloys are used extensively in orthopaedic implants due to their low cytotoxicity and high mechanical strength. However these issues can also limit full implant functionality, particularly for patients with complex orthopaedic issues. The surfaces of Ti-based implants do not typically induce strong mechanical interlocking, and the elastic modulus mismatch between the implant and host bone can lead to stress shielding and bone resorption. These issues often necessitate painful and costly revision surgeries. Major strategies in solving these problems include the use of alternate fabrication processes such as selective laser melting (SLM), surface coating with bone-like minerals, and the use of hydrogels as temporary intermediaries between the implant and growing host tissue.