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Stem Cell-Macrophage Interactions Regulate Vertebrate Muscle Regeneration: Insights from Zebrafish

thesis
posted on 01.07.2019 by NILAKSHI DHANANJANI DHANUSHIKA RATNAYAKE
Skeletal muscle displays a remarkable ability to repair in response to injury. This is mainly due to a specific stem cell population. These stem cells are in turn regulated by components present in the surrounding environment. Macrophages are a key immune cell type present in this environment and this thesis assessed their role using a zebrafish model. This work identified specific macrophage-stem cell communications that control the stem cells ability to repair muscle. These identified modes of cell communication provide novel therapeutic targets that hold the potential to enhance muscle repair in diseased and aged conditions.

History

Principal supervisor

Peter Currie

Year of Award

2019

Department, School or Centre

Australian Regenerative Medicine Institute (ARMI)

Additional Institution or Organisation

Australian Regenerative Medicine Institute (ARMI)

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

Exports