Monash University

Embargoed and Restricted Access

Reason: Under embargo until July 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Stem Cell-Macrophage Interactions Regulate Vertebrate Muscle Regeneration: Insights from Zebrafish

posted on 2019-07-01, 04:47 authored by NILAKSHI DHANANJANI DHANUSHIKA RATNAYAKE
Skeletal muscle displays a remarkable ability to repair in response to injury. This is mainly due to a specific stem cell population. These stem cells are in turn regulated by components present in the surrounding environment. Macrophages are a key immune cell type present in this environment and this thesis assessed their role using a zebrafish model. This work identified specific macrophage-stem cell communications that control the stem cells ability to repair muscle. These identified modes of cell communication provide novel therapeutic targets that hold the potential to enhance muscle repair in diseased and aged conditions.


Principal supervisor

Peter Currie

Year of Award


Department, School or Centre

Australian Regenerative Medicine Institute (ARMI)

Additional Institution or Organisation

Australian Regenerative Medicine Institute (ARMI)

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences