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Sphingolipids in cardiac remodelling: Molecular mechanisms and potential therapeutic targets
thesis
posted on 2021-02-02, 03:37 authored by RUTH REBECCA MAGAYEThis thesis examines a class of lipids known as sphingolipids and their effects on heart cells. It also explores the potential for targeting the sphingolipid pathway for heart disease therapy in a mice ischemia reperfusion injury model.
History
Principal supervisor
Bing HuiAdditional supervisor 1
Bernard L FLynnYear of Award
2021Department, School or Centre
Public Health and Preventive MedicineAdditional Institution or Organisation
Baker Heart and Diabetes InstituteCampus location
AustraliaCourse
Doctor of PhilosophyDegree Type
DOCTORATEFaculty
Faculty of Medicine, Nursing and Health SciencesUsage metrics
Categories
- Medical biochemistry - lipids
- Other biomedical and clinical sciences not elsewhere classified
- Cardiology (incl. cardiovascular diseases)
- Metabolic medicine
- Biochemistry and cell biology not elsewhere classified
- Plant cell and molecular biology
- Animal cell and molecular biology
- Pharmacology and pharmaceutical sciences not elsewhere classified
- Medical biochemistry and metabolomics not elsewhere classified
Keywords
cardiac remodellingcollagen synthesiscardiac fibroblastscardiac myocytesdihydrosphingosine 1 phosphatedihydrosphinganineischemia reperfusion injuryhypertrophyfibrosisdihydroceramide desaturase 1PI3K/Akt SignallingJAK/STAT signallingsphingolipidssphingosineTGFbMedical Biochemistry: LipidsMedicineCardiology (incl. Cardiovascular Diseases)Metabolic MedicineCell BiologyMolecular BiologyPharmacologyBiomarkers
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