Roberts_Thesis0320.pdf (4.66 MB)

Spatiotemporal regulation of anti-remodelling signalling pathways in primary human lung fibroblasts

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thesis
posted on 24.03.2020, 02:59 by Maxine Roberts
Idiopathic pulmonary fibrosis (IPF) is a devastating chronic lung disease characterised by fibrosis and scarring of lung tissue. Current approved therapeutics having limited efficacy and severe adverse effects. This thesis investigates the activation of the prostacyclin receptor (IPR), as a potential therapeutic approach for the treatment of IPF. Using targeted FRET biosensors to investigate cAMP and ERK signalling with high spatial and temporal resolution, a complex relationship was discovered between IPR signalling and phenotypic outcome The most significant result was the reversal of efficacy at phenotypically relevant readouts, demonstrating that sustained cAMP signalling may be important for IPF therapeutics.

History

Campus location

Australia

Principal supervisor

Michelle Halls

Additional supervisor 1

Steven Charlton

Additional supervisor 2

Elizabeth Rosethorne

Year of Award

2020

Department, School or Centre

Drug Discovery Biology

Additional Institution or Organisation

University of Nottingham

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

Exports

Exports