File(s) under permanent embargo

Reason: Under embargo until October 2020. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library, or by emailing document.delivery@monash.edu

Smart Drug Delivery And Image-Guided Therapy for Cancer with Modified Carbonate Apatite Nanoparticles

thesis
posted on 21.10.2019, 05:42 by AHSANUL KAISER
Nanoparticles-based drug delivery research that led to a promising and viable technology platform has been accepted as an alternative drug delivery system to reduce limitations of the conventional chemotherapy. Recently, inorganic biodegradable pH-sensitive carbonate apatite (CA), a potential drug nanocarrier have been shown to confer great advantages to carry the anti-cancer drugs as well as genetic materials in an efficient and targeted manner. Here we present a different fabrication approach for CA modified with Barium salt as a typical entity of therapeutic importance to reduce the complex diameter and thus to increase the payload capacity for enhanced intracellular transport of different types of therapeutics, such as synthetic anti-cancer drug (DOX, doxorubicin) and co-delivery of ICG and DOX to cancer cell lines.

History

Campus location

Malaysia

Principal supervisor

Mohamed Hisham Jaward

Additional supervisor 1

Dr. Masuduzzaman Bakaul

Additional supervisor 2

Associate Professor Dr. Md. Ezharul Hoque Chowdhury

Additional supervisor 3

Dr. Pushpamalar Janarthanan

Year of Award

2019

Department, School or Centre

School of Engineering (Monash University Malaysia)

Course

Doctor of Philosophy

Degree Type

DOCTORATE