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STRUCTURAL INSIGHTS INTO THE MOLECULAR MECHANISM OF THE RECOGNITION OF LIPID-BASED ANTIGENS BY NATURAL KILLER T CELL RECEPTORS

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thesis
posted on 07.09.2017 by PRAVEENA THIRUNAVUKKARASU
This research focused on one kind of immune cells called Natural Killer T cells. Natural killer T cells play an important role in regulating immune responses in conditions like infection, allergy, asthma and cancer. In this PhD, a new population of Natural killer T cells was identified that could be activated by a drug presently in clinical trials for treating various forms of cancer. With the help of cutting edge technology like X-ray crystallography, the interaction between the Natural Killer T cell and the drug is understood at their atomic level that would aid in designing new therapeutic agents for treating various human diseases.

History

Principal supervisor

Jamie Rossjohn

Year of Award

2017

Department, School or Centre

Biochemistry and Molecular Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

Exports

Keyword(s)

Exports