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Role of the Bidirectional Nuclear Transporter Importin 13 in Stress

thesis
posted on 15.04.2019, 04:42 by KATARZYNA ANNA GAJEWSKA
The transport of molecules into and out of the nucleus of the eukaryotic cell is carried out by a family of proteins called the “Importins”. When cells are exposed to environmental stresses that cause damage to the cell, transport carried out by Importins is inhibited. I have shown that a member of this family, Importin 13, is unlike most Importins and can continue to carry out transport of proteins in cells exposed to stress, and show that Importin 13 plays a key role in determining whether the cell should try to recover from the damage or induce cell death.

History

Principal supervisor

Kylie Wagstaff

Year of Award

2019

Department, School or Centre

Biochemistry and Molecular Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

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