Embargoed and Restricted Access
Reason: Under embargo until 10 June 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library.
Role of miR-21 in the downregulation of Sema5A protein in glioblastomas
Glioblastoma is the most aggressive type of brain tumor and is extremely resistant to most chemotherapies. Sema5A is a transmembrane protein recently found to be essential for controlling glioblastoma cell growth and migration. miR-21 was found to downregulate the expression of Sema5A, which results in glioblastoma cell proliferation. This research illustrated that Sema5A masking oligonucleotides approach successfully reduced glioblastoma cell proliferation, migration, and colony formation by preventing miR-21 from binding on to the 3’UTR of Sema5A. These findings suggest that miRNA-masking oligonucleotides are potential therapeutics for glioblastomas.