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Role of diet, microbiota and short-chain fatty acids in health and disease

thesis
posted on 01.06.2020 by JIAN KAI TAN
This thesis examines how diet connects our commensal gut bacteria to host physiology and the immune system. Gut bacteria, or the gut microbiota, can break down dietary fibre into short-chain fatty acids (SCFA). SCFA can influence the response of the immune system by binding to receptors such as GPR43 and GPR109A. Activation of these receptors were found to be important in regulating gut epithelial response as well as gut immune cell responses, required for protecting against models of human inflammatory bowel disease and against food allergy.

History

Principal supervisor

Mibel Aguilar

Year of Award

2017

Department, School or Centre

Biochemistry and Molecular Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

Exports

Categories

Exports