Monash University

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Reason: Under embargo until March 2020. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Role of Nitric Oxide and Oxidative Stress on Cardiorenal Syndrome Type 2

posted on 2019-03-26, 03:34 authored by BEVERLY GIAM
Heart failure affects 1 in 20 Australians. Approximately half of these patients develop kidney failure and this is termed cardiorenal syndrome. There are currently no treatments for kidney dysfunction in patients with cardiorenal syndrome. The current thesis investigates the pathways involved in the pathogenesis of this disease state. In particular, the pathogenic roles of oxidative stress and nitric oxide deficiency were explored. Accordingly, potential therapeutic interventions that can target these pathways were tested. In conclusion, treatments that can target the pathological imbalance between oxidative stress and nitric oxide holds strong promise in the treatment of cardiorenal syndrome.


Principal supervisor

David Martin Kaye

Additional supervisor 1

Niwanthi Rajapakse

Year of Award


Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Baker Heart and Diabetes Institute

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences