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Role of Neisseria gonorrhoeae secreted outer membrane vesicles in immune evasion

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posted on 2023-03-16, 02:43 authored by Subhash Dhital

Neisseria gonorrhoeae is a bacterial pathogen that causes gonorrhea, a sexually transmitted infection. Infections can remain asymptomatic or lead to several inflammatory diseases. The thesis is focused on how our immune system senses and responds to pathogenic Neisseria. By using clinical isolates of Neisseria gonorrhoeae, the thesis identified extracellular vesicles released by the bacteria to affect the initial response of the immune system. These responses change depending on the bacterial strain used. This has improved our understanding how the immune system responds to pathogenic Neisseria and open up new avenues to dampen excessive inflammation.


Principal supervisor

Principal supervisor

Additional supervisor 1

Pankaj Deo

Year of Award


Department, School or Centre

Biochemistry and Molecular Biology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences