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Reason: Under embargo until 30 December 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library.
Role of G protein-coupled receptor 139 in cognitive functions in zebrafish
thesis
posted on 2022-12-26, 04:48 authored by NISA ROYG protein Coupled Receptor 139 (GPR139) is an evolutionarily conserved orphan receptor involved in controlling motivation and reward. In the zebrafish, GPR139 is exclusively expressed in the ventral habenula, a region of the brain that mediates aversive responses. By combining immunofluorescence technique, behavior, and Ca2+ imaging recordings in slice culture, we demonstrate that GPR139 signalling in the habenula plays a differential role in multiple phases of fear conditioning via modulation of habenula neural activities in the zebrafish.
