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Role of CD53 in Leukocyte Trafficking

posted on 17.09.2019, 03:12 by LOUISA YEUNG
Migration of immune cells around the body is critical for effective immune and inflammatory responses. Tetraspanins are molecules on the surface of immune cells that contribute to immune cell function. In this thesis, we examined the role of one tetraspanin, CD53, in immune cell migration. We found that CD53 is particularly important in enabling immune cells to migrate out of blood vessels. The absence of CD53 resulted in delayed inflammation, but did not impact on system-wide autoimmunity. This thesis provides new information on the function of CD53 in development of the inflammatory response.


Principal supervisor

Michael Hickey

Additional supervisor 1

Mark Wright

Year of Award


Department, School or Centre

Medicine - Monash Health

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences

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