Monash University

Embargoed and Restricted Access

Reason: Under embargo until 31 August 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Repurposing drugs to improve chemotherapy outcomes in breast cancer

posted on 2020-07-31, 06:35 authored by AESON CHANG
Breast cancer impacts many lives. Cognitive side effects and poor survival in women with breast cancer remain significant clinical challenges. This thesis 1) identifies unanticipated effects of chemotherapy on nerves and receptors that regulate the stress response which adversely impacts survival; and 2) clarifies the role of inflammation in cognitive side effects caused cancer and chemotherapy. This thesis highlights the opportunity to repurpose readily available drugs to improve the effects of chemotherapy on the cognition and survival of women with breast cancer


Campus location


Principal supervisor

Erica Kate Sloan

Additional supervisor 1

Adam K Walker

Year of Award


Department, School or Centre

Drug Discovery Biology


Doctor of Philosophy

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences