Repurposing drugs to improve chemotherapy outcomes in breast cancer

Breast cancer impacts many lives. Cognitive side effects and poor survival in women with breast cancer remain significant clinical challenges. This thesis 1) identifies unanticipated effects of chemotherapy on nerves and receptors that regulate the stress response which adversely impacts survival; and 2) clarifies the role of inflammation in cognitive side effects caused cancer and chemotherapy. This thesis highlights the opportunity to repurpose readily available drugs to improve the effects of chemotherapy on the cognition and survival of women with breast cancer