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Reproducing Spermatogenesis

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posted on 29.08.2017, 00:02 authored by Queenie V. Neri
Germ cells isolated from testicular tissue or derived from embryonic stem cells represent a possible treatment option for children who have survived cancer and for azoospermic men. Self-renewal of spermatogonia stem cells is the foundation for sustaining spermatogenesis throughout life. In recent years, spermatogonia transplantation in mammals has been carried out successfully and, more recently, the appearance of germ cell lines derived from embryonic stem cells has rendered the treatment or prevention of azoospermia conceivable. In our laboratory, we have identified and labeled human spermatogenic cells at various steps of differentiation and carried out their xenogeneic transplantation into recipient gonads. In addition, by appropriately modifying culture conditions, we have been able to propagate mouse spermatogonia stem cells in vitro.


Principal supervisor

Graham Jenkin

Additional supervisor 1

David De Kretser

Year of Award


Department, School or Centre

Obstetrics and Gynaecology

Additional Institution or Organisation

Weill Cornell University

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences

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