Monash University
Revised copy (Mahbub Ullah 26654016)) (1)_Redacted.pdf (14.48 MB)

Renal Oxygenation and its Determinants in Chronic Kidney Disease

Download (14.48 MB)
Version 2 2019-02-27, 03:03
Version 1 2019-02-27, 02:37
posted on 2019-02-27, 03:03 authored by MD MAHBUB ULLAH
The thesis examines renal hypoxia and its role in the pathophysiology of CKD. The thesis identifies that renal tissue hypoxia is a common characteristic of CKD. The major drivers of this hypoxia probably differ depending on the etiology of the CKD. For example, fibrosis may be a critical event in driving hypoxia in adenine-induced-CKD while hyperfiltration may be a critical early event that drives hypoxia in diabetic CKD. The fact that renal dysfunction can be detected in adenine induced-CKD before renal hypoxia does not support the idea that renal hypoxia is an absolute requirement for progression of CKD. Thus, perhaps hypoxia might sometimes be a cause, sometimes a consequence, and sometimes both a cause and consequence, of CKD.


Principal supervisor

Roger George Evans

Additional supervisor 1

Lucinda M. Hilliard

Year of Award


Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation


Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences