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Renal Oxygenation and its Determinants in Chronic Kidney Disease

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thesis
posted on 27.02.2019, 03:03 authored by MD MAHBUB ULLAH
The thesis examines renal hypoxia and its role in the pathophysiology of CKD. The thesis identifies that renal tissue hypoxia is a common characteristic of CKD. The major drivers of this hypoxia probably differ depending on the etiology of the CKD. For example, fibrosis may be a critical event in driving hypoxia in adenine-induced-CKD while hyperfiltration may be a critical early event that drives hypoxia in diabetic CKD. The fact that renal dysfunction can be detected in adenine induced-CKD before renal hypoxia does not support the idea that renal hypoxia is an absolute requirement for progression of CKD. Thus, perhaps hypoxia might sometimes be a cause, sometimes a consequence, and sometimes both a cause and consequence, of CKD.

History

Principal supervisor

Roger George Evans

Additional supervisor 1

Lucinda M. Hilliard

Year of Award

2019

Department, School or Centre

Physiology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences