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Relaxin Family Peptide Receptor 4 (RXFP4) and its Ligand Insulin-like Peptide 5 (INSL5): Signalling Pathways and Physiological Roles

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posted on 2017-11-02, 01:51 authored by SHENG YU ANG
RXFP4 is recognised as the cognate G protein-coupled receptor for INSL5 although little is known about its signal transduction pathways and biological roles. This thesis investigates the signalling pathways activated by RXFP4 in a recombinant cell culture system and also identifies tissues and cell lines that endogenously express RXFP4, with subsequent evaluation of its endogenous signalling profile and possible physiological roles.


Campus location


Principal supervisor

Martina Kocan

Additional supervisor 1

Roger J Summers

Additional supervisor 2

Bronwyn A Evans

Additional supervisor 3

Dana S Hutchinson

Additional supervisor 4

Sabatino Ventura

Year of Award


Department, School or Centre

Drug Discovery Biology


Doctor of Philosophy

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences