Relaxin Family Peptide Receptor 4 (RXFP4) and its Ligand Insulin-like Peptide 5 (INSL5): Signalling Pathways and Physiological Roles

RXFP4 is recognised as the cognate G protein-coupled receptor for INSL5 although little is known about its signal transduction pathways and biological roles. This thesis investigates the signalling pathways activated by RXFP4 in a recombinant cell culture system and also identifies tissues and cell lines that endogenously express RXFP4, with subsequent evaluation of its endogenous signalling profile and possible physiological roles.