Monash University

Embargoed and Restricted Access

Reason: Under embargo until 30 September 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library.

Regulation of phosphoinositide signalling in breast cancer

posted on 2022-09-22, 13:14 authored by MARIAH PAIGE CSOLLE
Breast cancer is the most common cancer and second leading cause of cancer death in women worldwide. The protein PIPP is a tumour suppressor that is lost in a subset of breast cancers associated with poor prognosis. Loss of PIPP leads to increased tumour growth, however, decreased metastasis. This thesis contributes to our knowledge of the mechanisms by which PIPP regulates breast cancer. Understanding these complex signalling pathways is critical for the development of novel therapeutic strategies to treat breast cancer metastasis which causes 90% of breast cancer related deaths.


Principal supervisor

Christina Anne Mitchell

Additional supervisor 1

Dr Lisa Ooms

Year of Award


Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Biochemistry and Molecular Biology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences