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Regulation of phosphoinositide signalling in breast cancer

thesis
posted on 22.09.2022, 13:14 authored by MARIAH PAIGE CSOLLE
Breast cancer is the most common cancer and second leading cause of cancer death in women worldwide. The protein PIPP is a tumour suppressor that is lost in a subset of breast cancers associated with poor prognosis. Loss of PIPP leads to increased tumour growth, however, decreased metastasis. This thesis contributes to our knowledge of the mechanisms by which PIPP regulates breast cancer. Understanding these complex signalling pathways is critical for the development of novel therapeutic strategies to treat breast cancer metastasis which causes 90% of breast cancer related deaths.

History

Principal supervisor

Christina Anne Mitchell

Additional supervisor 1

Dr Lisa Ooms

Year of Award

2022

Department, School or Centre

Biochemistry and Molecular Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences