Monash University

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Reason: Under embargo until 13 October 2024. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Regulation of exhausted CD8+ T cell differentiation by IKZF transcription factors

posted on 2023-10-13, 05:07 authored by SINEAD MARIE READING
CD8+ T cells play a vital role in the immune system by killing infected and cancerous cells. Uncontrolled T cell activation can lead to self-damage warranting the need for mechanisms that dampen their function, such as T cell ‘exhaustion’. Unfortunately, cancer takes advantage of exhaustion to survive. Immunotherapies aim to reinvigorate exhausted T cells to improve clinical outcome. However, not all patients respond. Thus, there is a dire need to better understand the genetic regulators that induce exhaustion. My project focused on an important family of genetic regulators and whether their depletion can rescue exhaustion and improve response to immunotherapies.


Principal supervisor

Kim Jacobson

Additional supervisor 1

Ian Parish

Additional supervisor 2

Joseph Trapani

Year of Award


Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Biochemistry and Molecular Biology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses