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Reason: Under embargo until 5 August 2025. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Regulation of endosome maturation and breast cancer pathogenesis by INPP4B
thesis
posted on 2024-08-05, 08:53 authored by SABRYN AMINAH HAMILAThis thesis examined the role of an enzyme, INPP4B, in regulating the pathogenesis of human breast cancer. It identifies that INPP4B enhances the spread of breast cancer by regulating the function of small extracellular vesicles released by breast tumour cells. Moreover, this thesis reveals that INPP4B suppresses the ability of the body's immune system to recognise breast tumours, and may therefore prevent tumour detection and removal. These findings could be of significant benefit for improving the treatment of breast cancer patients with high INPP4B expression.
