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Regulation of Innate Antiviral Immunity by Host and Bacterial E3 Ligases

thesis
posted on 27.07.2020 by MELISSA NOEL SWEENEY
This thesis explores the interactions of host and bacterial proteins in the innate immune system during infection. The work presented shows that host proteins within the RIG-I-like receptor (retinoic acid-inducible gene-I-like receptors, RLRs) signalling cascade are subject to post-translational modification, and also binding by bacterial proteins, presumably as a means of regulating antiviral immunity to benefit the host or the pathogen, respectively. Uncovering the mechanisms by which host and bacterial proteins interact will help to identify novel therapeutic targets for combating infections.

History

Principal supervisor

Natalie Borg

Year of Award

2020

Department, School or Centre

Biochemistry and Molecular Biology

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Exports

Categories

Exports