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Regulation of Innate Antiviral Immunity by Host and Bacterial E3 Ligases
thesisposted on 27.07.2020 by MELISSA NOEL SWEENEY
In order to distinguish essays and pre-prints from academic theses, we have a separate category. These are often much longer text based documents than a paper.
This thesis explores the interactions of host and bacterial proteins in the innate immune system during infection. The work presented shows that host proteins within the RIG-I-like receptor (retinoic acid-inducible gene-I-like receptors, RLRs) signalling cascade are subject to post-translational modification, and also binding by bacterial proteins, presumably as a means of regulating antiviral immunity to benefit the host or the pathogen, respectively. Uncovering the mechanisms by which host and bacterial proteins interact will help to identify novel therapeutic targets for combating infections.