Monash University
Melissa Sweeney PhD Thesis 24-07-2020.pdf (21.81 MB)

Regulation of Innate Antiviral Immunity by Host and Bacterial E3 Ligases

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posted on 2020-07-27, 01:37 authored by MELISSA NOEL SWEENEY
This thesis explores the interactions of host and bacterial proteins in the innate immune system during infection. The work presented shows that host proteins within the RIG-I-like receptor (retinoic acid-inducible gene-I-like receptors, RLRs) signalling cascade are subject to post-translational modification, and also binding by bacterial proteins, presumably as a means of regulating antiviral immunity to benefit the host or the pathogen, respectively. Uncovering the mechanisms by which host and bacterial proteins interact will help to identify novel therapeutic targets for combating infections.


Principal supervisor

Natalie Borg

Year of Award


Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Biochemistry and Molecular Biology


Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses