Embargoed and Restricted Access
Reason: Under embargo until October 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Regulation of Clec16A by the RING E3 ubiquitin ligase RNF41
thesisposted on 09.10.2019, 04:32 authored by CARLOS GABLE
Clec16A is an essential cell protein that can regulate insulin secretion, immune cell processes and neurological functions. We discovered that the Clec16A protein can be regulated by another protein RNF41. Indeed, RNF41 interacts with and tags Clec16A for destruction. We have unravelled the pathway that underpins this regulation, and identified further proteins that are involved in this critical process. Understanding this novel pathway will facilitate a deeper understanding of important diseases such as cancer and inflammation.