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Regulation and role of mitochondrial transport in mouse oocyte and early embryogenesis

thesis
posted on 06.05.2022, 04:45 by INWON LEE
A spatial organization of cellular components plays a vital role in cell function. Oocyte mitochondria display dynamic changes in distribution during oocyte growth and maturation. However, how oocytes ensure efficient mitochondrial distribution to the correct destinations remains poorly understood. In this thesis, I investigated mitochondrial reorganization which can be mediated by passive mitochondrial streaming in mature oocytes and the roles of active trafficking mechanisms regulated by mitochondrial adaptor proteins in oocytes and early embryogenesis. These studies will provide new insights into how mitochondrial organization in the cytoplasm impacts oocytes and embryo viability.

History

Principal supervisor

John Carroll

Additional supervisor 1

Deepak Adhikari

Additional supervisor 2

Mike Ryan

Year of Award

2022

Department, School or Centre

Anatomy and Developmental Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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