Regulation & Function of Reactive Astrocytes in the Primate Brain: A Novel Role for NogoA

This thesis explores the regulation and function of injury-responsive support cells in the brain after injury. It demonstrates that age-dependent differences in support cell regulation are responsible for the better capacity for younger brains to recover after brain injuries, compared to adults. It also identifies a never before described link between these support cells and a major blocker of brain repair, contributing to suppressing inflammation following stroke. These findings have clinical implications for the development and testing of treatment strategies for brain injuries.