Real-time Soft Probing of Cardiac Organoids Monitoring

Cardiovascular diseases are the leading cause of death around the world. Stem cell-derived cardiac organoids, which are in-vitro three-dimensional and self-organizing multi-type cellular structures, have attracted significant attention as a promising platform for pre-clinical drug screening, cardiotoxicity assessment, and disease modeling. This thesis work contributes to real-time soft probing of cardiac organoids, enabling the monitoring of contractility, electrophysiology, and metabolism in real-time and iv in-situ. These integrated systems offer a suite of new diagnostic options for assessing cardiac organoids.