L142 PhDThesisReengineeringLumbarMicrodiscectomyFromtheBenchtotheBedsideFinalMaySubmitted_Redacted.pdf (45.09 MB)

Re-Engineering Lumbar Microdiscectomy: From the Bench to the Bedside

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thesis
posted on 21.03.2019, 00:52 by CHRISTOPHER DENIS DALY
This thesis explores ways to re-engineer lumbar discectomy surgery, the most commonly performed spine surgery in the word, via pre-clinical and clinical investigation. The preclinical investigation consists of developing a large animal model of the post lumbar discectomy intervertebral disc and developing a new therapy for disc degeneration using mesenchymal progenitor cells, a type of adult stem cell, pre-treated with the drug pentosan polysulfate. The clinical investigation consists of a survey of Australasian neurosurgeons characterising their lumbar discectomy practices and the protocol for a clinical trial investigating the role, if any, of activity restrictions following lumbar discectomy.

History

Principal supervisor

Tony Goldschlager

Additional supervisor 1

Peter Ghosh

Additional supervisor 2

Graham Jenkin

Year of Award

2018

Department, School or Centre

Surgery - Monash Health

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences