Final e-Thesis Ruchika Ojha.pdf (13.31 MB)

PtII, PtIII and PtIV Complexes from Chemical and Electrochemical Oxidation of organoamidoplatinum(II) Compounds

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posted on 13.08.2017, 23:52 by RUCHIKA OJHA
A detailed study of the chemical and electrochemical oxidation of a platinum(II) organoamide complex [Pt{(p-BrC6F4)NCH2CH2NEt2}Cl(py)], a representative of a class of rule breaker anticancer platinum(II) compounds. The compounds obtained after the chemical oxidation are organoenamineamide platinum(II) complexes for eg [Pt{(p-BrC6F4)NCH=CHNEt2}Cl(py)] in which the organoamide ligand is oxidised in addition to the Platinum(IV) complex [Pt{(p-BrC6F4)NCH2CH2NEt2}Cl(py)(OH)2] in which metal centre is oxidised. Electrochemical oxidation of [Pt{(p-BrC6F4)NCH2CH2NEt2}Cl(py)] gives rise to a rare monomeric platinum(III) species. Conditions favouring formation and stabilisation of this monomeric platinum(III) species are sought in this study. The rearrangement of this monomeric platinum(III) species produces [Pt{(p-BrC6F4)NCH=CHNEt2}Cl(py)] with oxidised ligand.

History

Campus location

Australia

Principal supervisor

Alan Bond

Year of Award

2017

Department, School or Centre

Chemistry

Course

Doctor of Philosophy

Degree Type

Doctorate

Faculty

Faculty of Science

Exports

Exports