Proteomic and phosphoproteomic studies of monocyte recruitment and macrophage polarisation

The balance between inflammatory and anti-inflammatory monocytes and macrophages, specialised white blood cells, is important in the development versus resolution of inflammatory diseases like atherosclerosis. This thesis describes studies of the global protein profiles in different types of macrophages and to investigate the mechanism of monocytes and macrophages being recruited to the sites of inflammation. This thesis will contribute to an improved understanding of monocyte recruitment and will guide the development of effective atherosclerosis therapies