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Protecting the newborn brain at birth

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thesis
posted on 08.10.2018, 08:11 by JAMES DIMITRIOS SAMUEL ARIDAS
Each year 4 million babies are starved of oxygen at birth, leading to permanent brain injury. Treatment options for these babies are limited, particularly in low income countries. The set of studies described in this thesis considered new neuroprotective therapies for babies that are starved of oxygen at birth. Using newborn lambs, we examined three treatments; umbilical cord blood cells collected at birth, body cooling and administering the natural antioxidant melatonin. Results showed that novel treatment strategies could reduce permanent brain injury in newborn lambs and these could be applied in either low or high income birth settings worldwide.

History

Principal supervisor

Suzanne Lee Miller

Additional supervisor 1

Graham Jenkin

Additional supervisor 2

Tamara Yawno

Year of Award

2018

Department, School or Centre

Obstetrics and Gynaecology

Additional Institution or Organisation

The Ritchie Centre, Hudson Institute of Medical Research

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences