Monash University
Protecting the newborn brain.pdf (253.64 MB)

Protecting the newborn brain at birth

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posted on 2018-10-08, 08:11 authored by JAMES DIMITRIOS SAMUEL ARIDAS
Each year 4 million babies are starved of oxygen at birth, leading to permanent brain injury. Treatment options for these babies are limited, particularly in low income countries. The set of studies described in this thesis considered new neuroprotective therapies for babies that are starved of oxygen at birth. Using newborn lambs, we examined three treatments; umbilical cord blood cells collected at birth, body cooling and administering the natural antioxidant melatonin. Results showed that novel treatment strategies could reduce permanent brain injury in newborn lambs and these could be applied in either low or high income birth settings worldwide.


Principal supervisor

Suzanne Lee Miller

Additional supervisor 1

Graham Jenkin

Additional supervisor 2

Tamara Yawno

Year of Award


Department, School or Centre

Clinical Sciences at Monash Health

Additional Institution or Organisation

Obstetrics and Gynaecology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences