Promoting Tissue Regeneration by Delivering Engineered Factors Derived from Regulatory T Cells

Acute muscle injuries trigger inflammation that’s essential for healing but can also cause damage if uncontrolled. We found that a molecule called interleukin‑10 (IL‑10), released by special immune cells (Tregs), is vital for turning off harmful inflammation and helping muscle cells recover. In mice lacking IL‑10 in these cells, muscle repair was poor. IL‑10 works by blocking a pro‑inflammatory signal (IFN‑γ) in scavenger cells (macrophages), guiding them to support healing. To boost recovery further, we created a new therapy combining IL‑10 with an antibody against IFN‑γ. This “two‑in‑one” treatment greatly improved muscle repair in severe injury models, offering a promising new approach for patients.<p></p>