Promoting Tissue Regeneration Via Monocyte Delivery

The thesis explores harnessing the body's innate inflammatory response to optimize tissue healing post-injury. It investigates advancing cell-based therapies, focusing on utilizing the delivery of monocytes for tissue regeneration. A novel monocyte-based therapy is developed, involving priming monocytes with immunomodulators before delivery to the injury site. Through systematic screening, the most effective immunomodulators for priming monocytes are identified. Interestingly, primed monocytes exhibit enhanced capability for tissue regeneration, notably in mouse muscle injury models. Furthermore, the thesis explores the mechanism by which primed monocytes may facilitate tissue regeneration, providing valuable insights for future regenerative medicine strategies.